Who better to answer this question than the creator of Lifesighs, Chris Shea?
“I began by calling my cards Lifesighs because that’s what I think life does. Sigh. Originally I conceived the name Lifesighs for a newspaper column I wrote, but the editor didn’t care for the name. He used Chris Shea instead. So I wrote the word on a piece of paper and vowed someday I would use it!