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Which specific enzyme is targeted by the toxin most likely responsible for the deadliest effects of Amanita phalloides?

April 26, 2017amanita deadliest enzyme likely phalloides responsible toxin

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Which specific enzyme is targeted by the toxin most likely responsible for the deadliest effects of Amanita phalloides?

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“Their major toxic mechanism is the inhibition of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA)…Without mRNA essential protein synthesis and hence cell metabolism grind to a halt and the cell dies.