Which of the following statements is TRUE with respect to enzymopathies (enzyme deficiencies)?
A. Enzymopathies are almost always recessive. B. Some of the pathophysiological consequences of enzymopathies can be attributed to accumulation of the substrate of the deficient enzyme. C. A single patient can have loss of function in more than one enzyme due to the deficiency of an enzyme cofactor. D. All of the above are correct. E. None of the above are correct.