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Which of the following is FALSE regarding the benefits of metformin therapy for type 2 diabetes?

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Which of the following is FALSE regarding the benefits of metformin therapy for type 2 diabetes?

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A. Metformin therapy may decrease LDL-C and triglyceride levels. B. Metformin has neutral effects on weight gain or may cause weight loss. C. Metformin therapy may improve insulin resistance. D. Metformin therapy may decrease hemoglobin A1C levels by 3% to 5%. • Which of the following is TRUE regarding the effects of metformin on macrovascular complications of diabetes as demonstrated in the UKPDS study? A. No benefits on CVD were found in patients treated with metformin. B. Metformin significantly reduced the occurrence of MI only. C. Metformin significantly reduced all-cause mortality only. D. Metformin significantly reduced the occurrence of MI, all-cause mortality, and all macrovascular complications. • Which of the following is an adverse effect specific to thiazolidinedione therapy? A. Hyperglycemia B. Hypoglycemia C. Anemia D. Weight gain • Pioglitazone has shown favorable effects on lipid profiles in patients with diabetes mainly due to: A. Agonism of PPAR-γ B. Partial agonism

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