Which observations from the complete blood cell count predict mortality for hospitalized patients?
GROUND: Information on the prognostic utility of the admission complete blood count (CBC) and differential count is lacking. OBJECTIVE: To identify independent predictors of mortality from the varied number and morphology of cells in the complete blood count defined as a hemogram, automated five cell differential count and manual differential count. DESIGN: Retrospective cohort study and chart review. SETTING: Wishard Memorial Hospital, a large urban primary care hospital. PATIENTS: A total of 46,522 adult inpatients admitted over 10 years to Wishard Memorial Hospital-from January 1993 through December 2002. INTERVENTION: None. MEASUREMENTS: Thirty-day mortality measured from day of admission as determined by electronic medical records and Indiana State death records. RESULTS: Controlling for age and sex, the multivariable regression model identified 3 strong independent predictors of 30-day mortality-nucleated red blood cells (NRBCs), burr cells, and absolute lymphocytosis-each of whi