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which medication is more effective in preventing second strokes that are caused by blocked blood vessels in or leading to the brain.

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which medication is more effective in preventing second strokes that are caused by blocked blood vessels in or leading to the brain.

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Patients will receive either aspirin or ticlopidine twice a day for at least two years and will not know which medication they are receiving. All medications and tests associated with the study will be free. Both aspirin and ticlopidine prevent the blood cells responsible for clotting (platelets) from sticking together. aspirin accomplishes this by working inside the platelets to block an enzyme responsible for the clumping. Ticlopidine, which is manufactured by Hoffmann-La Roche and is being provided free of charge, works on the cell surface and has a broader effect. “Earlier research has shown that ticlopidine may work better than aspirin in certain groups of people, specifically, African Americans, women and diabetics,” Gorelick said. “Also, research has shown that ticlopidine can reduce the risk for stroke by as much as 50 percent more than aspirin in the first year of treatment.

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