Which mechanisms underlie the age-related attenuation of proteasome activity?
Investigations into the mechanisms underlying the change in proteasome activity during aging are usually performed by comparing cells and tissues from individuals (mostly rats) of different ages, since experimental models mimicking the aging process are difficult to obtain. In particular, the effect of aging on proteasome activity cannot be mimicked by proteasome knockout models, as they are non-viable [37]. Therefore, data summarized in this review were obtained from studies utilising many different tissues from various species. In most investigations into age-dependent changes in proteasome activity, a decrease in PGPH activity was detected, while changes in chymotrypsin-like and trypsin-like activity were not as consistent. Thus, a general decrease in 20S/26S proteasome concentration, as found in aging keratinocytes [50] and in a human fibroblast cell line that was experimentally induced to senescence-like phenotype by incubation with low dose proteasome inhibitors [54], cannot be t
Related Questions
- If a Hopkins physician earns credit elsewhere by attending or participating in a CME activity, is Hopkins going to track these credits for him/her?
- Which mechanisms underlie the age-related attenuation of proteasome activity?
- What mechanisms underlie species diversity in sexual dimorphism of behavior?
