Which is truly healthier to consume, sugar in its natural form, or man-made ones like Splenda?
The difference between sugar and some of its substitutes can be minimal as in the case of Splenda. Splenda is manufactured by selective replacement of three of sucrose’s hydroxyl groups with chlorine atoms. This is a minimal alteration in structure that results in a product that is 320 – 1,000 times as sweet as sucrose, making it roughly twice as sweet as saccharin and four times as sweet as aspartame. On the other hand, the difference between sucrose and other substitutes can be rather dramatic as in the case of aspartame in which aspartame is a dipeptide, consisting of two amino acids connected together with an amide linkage with one of the amino acids containing a methyl ester. These are very different structures. In the case of the sucrose substitutes the body responds to much smaller quantities of the compounds as the receptors must be more responsive to the substitutes than to the sucrose, thereby affecting a person’s blood sugar much less.
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