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Which four of the following statements regarding polycystic ovary syndrome (PCO) are true?

April 26, 2017ovary PCO polycystic statements SYNDROME

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Which four of the following statements regarding polycystic ovary syndrome (PCO) are true?

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A,B,C,E. In women with polycystic ovary syndrome (PCO), elevated ovarian androgen production: – Stimulates pilosebaceous units, causing hirsutism and acne – Inhibits hepatic sex hormone-binding globulin (SHBG) production, increasing the amount of bioavailable testosterone in the circulation – Inhibits folliculogenesis, decreasing estradiol (E2) synthesis – Stimulates peripheral conversion of androstenedione (A4) to estrone (E1) The acyclic estrogen production unopposed by progesterone stimulates endometrial proliferation (increasing the risk of endometrial carcinoma) and potentiates the disease by further stimulating LH release (estrogen-positive feedback), and inhibiting FSH (estrogen-negative feedback). Estrogen increases bone formation.