Which Fluoroquinolones Are Responsible?
A study evaluating the dose of individual fluoroquinolones required to induce 80% incidence of clonic convulsions in mice found that levofloxacin was among the least likely agents to cause convulsions, particularly when co-administered with NSAIDs (Table 3). In contrast, the ability of enoxacin to cause convulsions was dramatically increased when biphenyl acetic acid was co-administered. Phase IV results also support the safety of levofloxacin showing that the incidence of clonic convulsions caused by levofloxacin alone was 1 in 250,000. When levofloxacin was used in combination with NSAIDs, this increased only to 1 in 53,000. Table 3.
