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Which drugs produce the worst Fetal Syndrome when the mother uses them during pregnancy?

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Which drugs produce the worst Fetal Syndrome when the mother uses them during pregnancy?

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Alcohol, by far, is the worst drug. It produces the permanent teratologic effects caused by alcohol: abnormal facial characteristics, organ developmental defects, including brain underdevelopment. All other recreational drugs (legal or illegal) produce marked, but temporary, effects on the fetus. However, more research would be helpful in identifying the precise effects of recreational drugs on the fetus.

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