Which Comes First: Knee Malalignment or Joint Space Narrowing?
malalignment is strongly associated with increasing structural damage in osteoarthritis (OA) progression others have found that malalignment is not associated with knee OA incidence. Clarification of the temporal sequence between knee malalignment and OA occurrence is important because it will help us to understand the etiology of OA and guide us to develop effective clinical and preventive strategies for the disease. We performed sequence symmetry analysis to assess the temporal sequence between the knee alignment and joint space narrowing (JSN) in the Boston Osteoarthritis of the Knee Study (BOKS).
