Which cell types express Dysferlin?
The highest expression of Dysferlin protein is found in skeletal and cardiac muscle, and kidneys. Dysferlin expression has also been reported in satellite cells (SCs) and certain immune cells like monocytes and macrophages. In addition, a shorter transcript of 4kb is detectable in the brain tissue and faint, lower molecular weight bands can be detected in the brain stem, spinal cord and sciatic nerve (Glover and Brown, Traffic 8: 785-794; deLuna et al., J of Neuropath Exp Neuro 63 (10): 1104-1113; Anderson et al., Human Molecular Genetics 8 (5): 855-861). Recently Dysferlin expression was also detected in human placental microvillus syncytiotrophoblasts (Vandre et al., Biol Reprod 77: 533-542). Dysferlin positive staining is also observed in case of stomach, lung, liver and spleen tissue from rats (Anderson et al., Human Molecular Genetics 8 (5): 855-861). 3. Where is Dysferlin localized in the cell? Dysferlin is predominantly localized at the sarcolemma of skeletal muscle cells and ca
