Where is that interfering signal coming from?
One of the more frequent sources of interference on the 2 meter band is part of a computer (a PC, a server, or something similar). You’re monitoring the local repeater as you go to start the computer, and when you hit the computer power button, you hear noise on the radio. Or, you hear noise on the radio as you pass a certain room each day. This is called a “birdie”, and though it’s annoying, it is usually only noticeable when the antenna is very close to the offending computer, and nothing else is transmitting on the frequency.