Where Have All the Vessels Gone?
Bernard Thébaud1 and Steven H. Abman2 1 Department of Pediatrics, Division of Neonatology, Vascular Biology Group, University of Alberta, Edmonton, Alberta, Canada; and 2 Department of Pediatrics, Pediatric Heart Lung Center, University of Colorado School of Medicine and the Children’s Hospital, Denver, Colorado Correspondence and requests for reprints should be addressed to Bernard Thébaud, Department of Pediatrics, Division of Neonatology, Vascular Biology Group, University of Alberta, HMRC 407, Edmonton, AB, T6G 2S2, Canada. E-mail: bthebaud{at}ualberta.ca’ + u + ‘@’ + d + ”//–> ABSTRACT Bronchopulmonary dysplasia and emphysema are significant global health problems at the extreme stages of life. Both are characterized by arrested alveolar development or loss of alveoli, respectively. Both lack effective treatment strategies. Knowledge about the genetic control of branching morphogenesis in mammals derives from investigations of the respiratory system in Drosophila, but mechanisms
