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Many people find it difficult to obtain a satisfactory level of effects when smoking Salvia divinorum leaf. Usually this is because of insufficient dose, improper smoking technique, or low sensitivity to salvinorin A. The active principal of Salvia divinorum is a diterpenoid compound called salvinorin A. The average concentration of salvinorin A in Salvia divinorum leaves is about 2.5 mg per gram. A moderate smoked dose of salvinorin A for a person of average sensitivity is 0.5 mg. Therefore, 200 mg (1/5 gram) of average-strength Salvia divinorum leaves contains enough salvinorin A to produce moderate effects in a person of average sensitivity. In practice however, one may need to use about twice this dose (i.e. 400 mg, or 2/5 gram), because some salvinorin A is probably decomposed during burning, some is lost in smoke that escapes during smoking, and some is not fully absorbed in the lungs and is thus lost upon exhaling. Four hundred milligrams of Salvia divinorum leaf produces quite
