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DESCRIPTION Bupropion is an antidepressant in a class by itself, somewhat different from other antidepressants (tricyclic antidepressants and selective serotonin reuptake inhibitors). However, like other antidepressants, bupropion’s effect in neuropathy has nothing to do with depression. Rather, it has to do with drug’s ability to interfere with chemical messengers, called neurotransmitters, in the brain. This drug affects dopamine and norepinephrine, which in turn affects the way the brain perceives pain. Bupropion demonstrated greater effectiveness than placebo in a study in 46 patients with neuropathy due to various causes, according to Neurology. Nearly 75% of patients rated their pain as improved or much improved with bupropion compared to no significant change with placebo. A major benefit of this medication compared to selective serotonin reuptake inhibitors (SSRIs) is that it is less likely to cause negative sexual side effects. ORIGINAL USES (ON-LABEL) Treatment of depression
