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DESCRIPTION Nexium is indicated for the treatment of erosive gastritis (damage to lower esophagus by acid reflux from stomach), moderate to severe heartburn, and reduction in reoccurance of duodenal ulcers. It acts by inhibiting proton pumps (hydrogen ion) in the stomach. This inhibition reduces the amount of acid produced by the stomach. ORIGINAL USES (ON-LABEL) Gastroesophageal reflux disease (GERD), severe erosive esophagitis; treatment of active duodenal ulcers in combination with antiinfectives for Helicobacter pylori infection MECHANISM OF ACTION Irreversibly inactivates proton pump in gastric parietal cells, which blocks the final step in secretion of hydrochloric acid; acid secretion is inhibited until additional enzyme is synthesized; inhibits basal and stimulated gastric acid secretion. POTENTIAL SIDE EFFECTS The most common side effects are headache (5%), diarrhea, nausea, flatulence (gas) abdominal pain and constipation. CAUTIONS • Contraindicated with hypersensitivity to o
