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DESCRIPTION Lamisil is indicated for the treatment of a fungal infection of fingernails and toenails due to tinea unguium. It acts by inhibiting the enzyme, squalene oxidase which blocks the synthesis of bacterial and fungal cell walls thus preventing growth. ORIGINAL USES (ON-LABEL) Tinea cruris, tinea corporis, tinea pedis; onychomycosis due to dermatophytes; cutaneous candidiasis; tinea versicolor; active against Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum. MECHANISM OF ACTION Inhibits fungal sterol biosynthesis, causing accumulation of squalene within the fungal cell and cell death. POTENTIAL SIDE EFFECTS Lamisil tablets may cause stomach and bowel upsets, changes in taste, headache, and aches or pains in the muscles and joints. If either preparation causes a rash a doctor should be consulted, as treatment may need to be discontinued if the rash worsens. CAUTIONS • Children • Terbinafine should be used with caution by people with chronic liver disease
