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DESCRIPTION Fluconazole is an oral antifungal medication that is used to treat a wide range of fungal diseases. Although a drug called amphotericin B is currently the FDA-approved drug to treat endophthalmitis caused by fungal infection, there are concerns about its potential to cause renal damage and the need to administer it by intravenous infusion, as reported in the Archives of the Spanish Society of Ophthalmology. Those risks are raised when it is given in conjunction with certain other drugs that the patient may be taking. In those instances, the physician may look to off-label anti-fungal drugs, such as fluconazole. ORIGINAL USES (ON-LABEL) Treatment of various fungal and yeast infections. NEWLY DISCOVERED USES (OFF-LABEL) Endophthalmitis POTENTIAL SIDE EFFECTS Headache, rash, nausea, vomiting, abdominal pain, diarrhea, upset stomach, taste perversion, serious skin reactions, liver toxicity. CAUTIONS • Do not take this drug at the same time as cisapride. • Notify your doctor if