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DESCRIPTION Anastrozole belongs to a class of drugs known as aromatase inhibitors; these drugs block aromastase (an enzyme) that is a major source of estrogen (a female hormone) in body. Anastrozole is typically given to patients with breast cancer to reduce hormone blood levels that contribute to tumor growth, but it may be particularly helpful for men whose infertility is associated with abnormal levels of hormones (testosterone and estrogen). Common side effects associated with the use of anastrozole include headache, diarrhea, nausea, back pain, weakness, and reduced energy. ORIGINAL USES (ON-LABEL) Advanced breast cancer in postmenopausal women with the disease progression following tamoxifen therapy, early ER-positive breast cancer in postmenopausal women, locally advanced or metastatic breast cancer (estrogen receptor-positive of hormone receptor unknown) in postmenopausal women. NEWLY DISCOVERED USES (OFF-LABEL) Infertility (male & female), McCune-Albright syndrome. POTENTIAL S
