Where are vitreous humour and inner limiting lamina components synthesised?
The source of vitreous and ILL macromolecules has been the subject of much speculation and it has only recently been clearly shown that these macromolecules can be synthesised by different cell types and synthesis can vary according to the developmental stage and possibly also with regard to different species. To date, most information has been derived from studies using mouse or chicken eyes and some caution should be exercised when extrapolating these data to human eyes. Furthermore, these studies use in situ hybridisation to detect mRNA expression, and it does not necessarily follow that the presence of a specific mRNA in a cell type will correlate with the biosynthesis of the corresponding protein. Source of vitreous collagens Using in situ hybridisation, several laboratories have studied mRNA expression of vitreous collagens type II and IX in the developing eye.16,17 Linsenmayer et al17 showed that, in the eye of the chicken embryo, type II collagen mRNA is expressed throughout th
