When William Pitt the Younger resigned over Catholic Emancipation..?
Pitt decided that parliamentary union of Ireland with England and Catholic emancipation must be accomplished. He achieved the legislative union in 1800 with the aid of a massive program of outright bribery. But his plan for Catholic emancipation met with the King’s adamant refusal. Pitt regarded it as so important that he would not remain in office in view of George III’s objections. That’s why he accordingly resigned in March 1801.