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When should the spring loading of the single-channel Research plus pipettes be deactivated?

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When should the spring loading of the single-channel Research plus pipettes be deactivated?

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For dispensing tasks in which a pipette tip is used over a long time or is slightly bended, it can be helpful to deactivate the spring loading of the tip cone by installing the locking ring. This can also be helpful for pipette tips which are not designed for the Eppendorf pipette cones.

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