When is it appropriate to evaluate the dosage of TOPAMAX in monotherapy?
Because dosage needs are highly individualized, a titration plan with stopping points at intermediate steps to evaluate patient response can avoid overshooting an optimal maintenance dosage. The cumulative data with topiramate suggest that 100 mg/day may be an appropriate first point at which to assess patient dosage needs. Most of the therapeutic effect of topiramate monotherapy was achieved with plasma concentrations of 4 to 10 µg/mL. 10 The approved dosage is 400 mg/day for monotherapy.
