When is a tree said to be curated?
A very important step in curating the TreeFam tree for a family is annotating the nodes in the tree that are considered to be correct. That is, once the curator has finished editing the phylogenetic tree for a family, the curator marks the nodes in the tree that are considered to be probably correct with `C’. A node is marked with `C’ if the curator is sure that (A) the subtree descending from that node contains every gene that it should contain (among the sequences already in the tree); and (B) the subtree does not contain any genes that it should not contain; and (C) the topology of the subtree is completely correct. If the curator has doubts about whether the node is correct, then the node is marked with `P’ (putative). In practice, when we mark nodes as `C’ or `P’, we only consider the topology with respect to the `core TreeFam species’: human, mouse, rat, chicken, Drosophila melanogaster and Caenorhabditis elegans. We do not include the fully sequenced fish genomes (zebrafish and
