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When is a pathology review indicated in endometrial cancer?

April 26, 2017cancer endometrial indicated pathology review

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When is a pathology review indicated in endometrial cancer?

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Kwon JS; Francis JA; Qiu F; Weir MM; Ettler HC Department of Gynecologic Oncology, M.D. Anderson Cancer Center, Houston, Texas, USA. jskwon@mdanderson.org OBJECTIVE: Discrepancies may exist between an original pathology report and formal pathology review, with subsequent implications for treatment. We conducted a study of pathology review in endometrial cancer from a population-based study to identify areas of discrepancy and effect on treatment. METHODS: This was a retrospective cohort study in Ontario, Canada from 1996 to 2000. We identified hysterectomy cases from patients with endometrial cancer that were subject to formal pathology review by a gynecologic pathologist at one of six tertiary care centers. Sarcomas and other rare histologic subtypes with fewer than five cases were excluded. We evaluated discrepancy between original pathology and review by demographics, stage, grade, and risk group. Four risk groups were defined: 1) low (stage I), 2) intermediate (stage I and II), 3)