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When hepatitis B vaccine and HBIG are administered to a newborn, should the doses be given in separate extremities?

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When hepatitis B vaccine and HBIG are administered to a newborn, should the doses be given in separate extremities?

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It is preferable to use separate extremities. If this is not possible, the two IM injections should be separated by at least one inch. This may be challenging in a newborn thigh.

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