When did Avandia come under intense scrutiny?
In 2007, Dr. Steven Nissen of the Cleveland Clinic analyzed 42 studies involving more than 28,000 people taking Avandia. His startling conclusions were that they had a 64% greater risk of death from heart problems and were 43% more likely to suffer heart attacks than those taking similar drugs or placebo. The results were published in the New England Journal of Medicine in May 2007. Barely a month later, the ADOPT study showed that women who take Avandia are at an increased risk of suffering bone fractures.
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