Whats the relationship between lean body mass and aminoglycosides?
Aminoglycoside antibiotics are just an example (probably the most frequent example) of a class of drugs that may have dosage adjustments made on the basis of lean body mass. That is because the aminoglycosides are highly water-soluble and distribute primarily to lean tissues (do not enter fatty tissues well), so lean body mass serves better as a predictor of plasma and lean tissue levels of drug relative to dosage than total body weight serves as a predictor.
