Whats the most common drug resistance transmitted for people just diagnosed?
There are a lot of different mutations that are transmitted. But in terms of how those mutations affect drugs, in particular, the ones we worry about most are resistance to non-nucleosides [NNRTIs], which would be [resistance to] Viramune and Sustiva. The reason for that is because those mutations, they tend to persist for a long time. Even in people who have been on Sustiva and then stopped it; they’ll still have the Sustiva mutation, so they can infect other people with that mutation. The other problem is that the single mutation can cause such high-level resistance. So if there were one class of drugs I would worry about, it would be those drugs. Just to explain to our audience: If you are diagnosed with HIV and along with the HIV you got the person’s HIV drug resistance and you don’t get a resistance test, when you begin a regimen, let’s say, with Atripla, it won’t work. Right. Not only will it not work; let’s say you’re infected with NNRTI resistance. So you’re resistant to Sustiv
