Whats the difference between drug tolerance and Tachyphylaxis?
1.Rapid desensitization to a toxic substance produced by inoculation with a series of small doses. 2.A rapidly decreasing response to a drug following administration of the initial doses tolerance=Drug tolerance is basically the body’s ability to adapt to the presence of a drug. The magnitude of the body’s response to a particular drug depends on two factors: •Concentration of the drug at its site of action •Sensitivity of the target site to the drug The sensitivity of the target cells is governed by genetic factors and adaptive changes by the body. Adaptive changes occur in response to the repeated exposure to a particular drug. The result is usually a loss of sensitivity to the drug. This decreased response is called tolerance Tolerance may be defined as a state of progressively decreased responsiveness to a drug as a result of which a larger dose of the drug is needed to achieve the effect originally obtained by a smaller dose. basically, what i get is that tachyphylaxis is not dose
