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Whats the difference between a conformer and a de novo structure?

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Whats the difference between a conformer and a de novo structure?

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Conformers are molecules with the same molecular structure (same number of atoms and same atoms are bonded within the molecule) but with a different 3-Dimension representation due to twisting of various internal bonds. A de novo structure, or de novo derivative, is a molecule that has actually been altered slightly rather than just contorted.

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