Whats the alternative to more complicated regression calculations (such as Deming or Passing-Bablock regression)?
You can collect the data very carefully to permit the application of other statistical calculations. Consider strategies to: • Expand the analytical range of the test results so ordinary linear regression statistics will be valid. • Reduce the variation of the comparison method by performing duplicate measurements, i.e., reduce the error in the x-value to better satisfy the assumption in ordinary linear regression. • Collect the data around the medically important decision concentrations, then analyze subsets of data using t-test statistics. • Interpret the data only at the mean of the data set to minimize the effect of the regression technique on the estimate of systematic error.
