What would raised blood urea nitrogen be like?
The period over which the concentration of oxytetracycline in the blood takes to fall to half its original concentration in the blood is 6-10 hours in adults with normal kidney function; and is reported to be 47-66 hours in patients with severe kidney impairment. In patients with normal kidney function, approximately 60 to 70% of a single oral dose of oxytetracycline is excreted in urine within 72 hours as active drug. Oxytetracycline does not appear to be broken down by the body and is passed unchanged mainly in urine by filtration through the kidneys. Increased urinary excretion of nitrogen and increased blood urea nitrogen concentrations, have been reported if the usual dosage of oxytetracycline is used in patients with impaired kidney function, and problems can occur. These could manifest themselves as signs and symptoms of severe ongoing kidney failure including nausea, vomiting, loss of appetite, a metallic taste in the mouth, bad breath, itching of the skin, pain and twitching i
