What would increased anti-nuclear antibodies in a blood test signify?
(Female, 40) A: High levels of anti-nuclear antibodies (ANAs) in a blood test are associated with rheumatic autoimmune diseases, particularly lupus (SLE). These levels can also be increased with some other inflammatory conditions or in quite healthy people, especially as you get older. On its own, you cannot interpret or explain the blood test result. It must be considered in the context of a range of factors including the reason the test was ordered, any symptoms experienced, diagnosis, age, type of test (varies between laboratories) and so on. I suggest that you make an appointment to see your doctor who can discuss with you the results of your test and advise of any further treatment or tests that may be required. Last reviewed: 04/01/2008 Disclaimer These answers provide general information endorsed by our experts at time of publication. They are not intended to take the place of medical advice. Please seek advice from a qualified health care professional.