What would happen if I had an allergic reaction to intravenous or oral bisphosphonates?
Allergies to bisphosphonates are very rare. Should you have an allergic reaction to an oral or an intravenous therapy, your doctor could deal with this as with any other medical allergic reaction using medications such as adrenaline, antihistamine and prednisone. Bisphosphonates do not remain in the blood circulation for very long and disappear rapidly by being deposited on the surface of bone or being removed through the kidneys. An allergic reaction would not be expected to last longer than the drug is circulating in the bloodstream, usually less than 48 hours. The medication that remains on the surface of bone would not cause an allergic reaction and would be similar whether you have taken this medication by mouth or by intravenous infusion. Allergic reactions are acute, short-term problems different from other side effects of medications and are rarely described with the bisphosphonates.
