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What would cause a frozen section to be inferior to a paraffin section?

April 26, 2017cause frozen inferior paraffin section

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What would cause a frozen section to be inferior to a paraffin section?

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• Slow, poor freezing produces large hexagonal ice-crystals within the tissue that can damage insoluble structural elements and cause displacement of water-soluble components. • Melting ice from mounting the frozen section on a room temperature slide causes water-soluble components of the cell to be displaced by the flow. • Water-soluble substances may wash out of the sections when unfixed wet or dry sections are placed in aqueous solutions (even aqueous fixatives).