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What will be the effect of standardization of the creatinine assay on GFR estimates?

April 26, 2017assay Creatinine estimates gfr standardization

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What will be the effect of standardization of the creatinine assay on GFR estimates?

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The National Kidney Disease Education Program is leading the process of standardization of the creatinine assays in all clinical laboratories. This is expected to be complete in 2008. After standardization, most clinical laboratories’ serum creatinine results will decline by 0.1- 0.3 mg/dL. The MDRD Study equation has been re-expressed for standardized serum creatinine. Use of the re-expressed MDRD Study equation with standardized serum creatinine improves the accuracy of GFR estimates using that equation. The Cockcroft and Gault equation has not been re-expressed for use with standardized serum creatinine. GFR estimates using the Cockcroft and Gault equation with standardized serum creatinine will generally be higher and less accurate than with non-standardized creatinine.