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What will be EPAs approach to implementing the revised Guidelines and the supplemental guidance?

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What will be EPAs approach to implementing the revised Guidelines and the supplemental guidance?

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Effective immediately, the Guidelines and Supplemental Guidance will serve as EPA’s recommendation to Agency risk assessors preparing cancer risk assessments. As EPA prepares cancer assessments under the Integrated Risk Information System (IRIS) program, as well as in other EPA programs, the Agency will begin to use the Guidelines and Supplemental Guidance. EPA also will consider the Guidelines and Supplemental Guidance along with other selection factors when EPA selects substances for reassessment in annual IRIS agendas (see for example, 70 FR 10616, March 4, 2005).

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