What was the purpose and design of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial?
The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial was a cancer prevention trial conducted by the U.S. National Cancer Institute (NCI) and the National Public Health Institute of Finland from 1985 to 1993. The purpose of the study was to determine whether certain vitamin supplements would prevent lung cancer and other cancers in a group of 29,133 male smokers in Finland. The 50- to 69-year-old participants took a pill daily for five to eight years that contained one of the following: 50 milligrams (mg) alpha-tocopherol (a form of vitamin E), 20 mg of beta-carotene (a precursor of vitamin A), both, or a placebo (inactive pill that looked like the vitamin). 2. What were the principal findings? ATBC researchers reported that men who took beta-carotene had an 18 percent increased incidence of lung cancers and an 8 percent increased overall mortality. Vitamin E had no effect on lung cancer incidence or overall mortality. The men taking both supplements had outcomes similar t
