What types of rDNA research always require IBC approval?
Any work with viral vectors, development of new strains of transgenic rodents, any development or production of transgenic or knockout plants or animals (other than mice), interference RNA, and cloning into microbial strains other than E. coli K-12 and its derivatives, Saccharomyces cerevesiae, S. uvarum, Bacillus subtilis, and B. licheniformis. Many E. coli strains widely used for cloning of short DNA segments (e.g. TOPP, BL21) are not exempt from review by the IBC. (See the NIH OBA FAQ – “Transgenic Animals and the Use of Recombinant DNA in Animals”).
