What types of compounds can be loaded into the ammonium liposomes?
The ammonium liposomes is used for active loading of small molecules that are weakly basic and lipophilic. Examples of compounds that have been successfully loading into ammonium liposomes include doxorubicin, vincristine, topotecan, and etc. These compounds typically have an amino/amine group with pKa values in the range of 7-9. They have limited water solubility and most importantly with Log P values > 0, meaning being lipophilic when deprotonated.
