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What tissues in the human body account for most of the increase in energy requirement during exercise?

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Muscle tissue accounts for a large proportion of the extra energy requirements of the body during exercise. This is because the process of contraction by a muscle tissue requires an energy source, therefore increases in frequency and force of contractions as in exercise will lead to increased energy requirement. So theres a simple relationship between work performed and energy input required, a bit like a car requiring more petrol/gas when going faster. The increase in energy requirement during exercise by muscle is an increase in the need for ATP. as ATP is required in order for the muscle cells (myocytes) to produce a contraction.

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