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What stimulates pepsinogen secretion from the chief cells?

April 26, 2017cells Chief secretion stimulates

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What stimulates pepsinogen secretion from the chief cells?

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There are a variety of factors that stimulates pepsinogen secretion. The first 2 listed are most important: • 1. Vagal activation: during cephalic phase, same mechanisms as for acid secretion, via acetylcholine and during the gastric phase, via distention and vago-vagal reflexes. • 2. Acid secretion will stimulate pepsinogen secretion, perhaps via local nerve plexus innervation and acetylcholine release • 3.