What specific problems in redox are responsible for disease?
Three generalized defects can result from redox disturbances that include: i) defects in the generation of energy; ii) defects in redox signaling pathways; and iii) increased oxidative stress. Each of these mechanisms has been implicated in a variety of diseases. For example, in mitochondrial disease, there is a bona fide defect in energy generation, resulting in decreased oxygen consumption, and ATP production. In contrast, stroke and re-perfusion injury results from both a decrease in ATP generation but is also associated with markedly increased oxidative stress.
