What side effects are most commonly associated with TOPAMAX for migraine prevention?
The most common adverse event associated with the use of TOPAMAX was paresthesia (defined as tingling in the extremities). However, severity was mild to moderate and discontinuation due to this effect was 7%. The most common adverse events associated with TOPAMAX 100 mg vs placebo were: paresthesia, 51% vs 6%; anorexia, 15% vs 6%; fatigue, 15% vs 11%; nausea, 13% vs 8%; diarrhea, 11% vs 4%; weight decrease, 9% vs 1%; taste alteration, 8% vs 1%. Of the 1135 patients exposed to topiramate in placebo-controlled studies, 25% discontinued due to adverse events, compared to 10% of the 445 placebo patients.
