What Should I Know About Tricyclic Antidepressants (TCAs)?
By Terry Mason Tricyclic antidepressants, or TCAs, are used to prevent migraines. They can decrease the frequency, severity, and duration of a migraine. The amount prescribed varies from person to person. TCAs are commonly taken once a day at bedtime. Your doctor will start you off with a low dose and increase the dose slowly every 1 to 2 weeks. Typically, people respond within 10 days. But the best results may not occur until after you’ve taken the medication for 4 to 8 weeks.