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What should I do if a normal cell stains positive with the BD ProEx™ C ICC method?

April 26, 2017BD CELL ICC method normal positive proex™ stains

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What should I do if a normal cell stains positive with the BD ProEx™ C ICC method?

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TOP2A and MCM2 are expressed in some proliferating cells and therefore it is possible to see some staining in morphologically normal appearing cells. However, the biomarkers are typically over-expressed in atypical cells. Therefore normal appearing cells that are positive for the markers should be reported as negative.