What should I discuss with my health care provider before using rectal promethazine?
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using promethazine, tell your doctor if you have: • a history of seizures; • heart disease or high blood pressure; • liver or kidney disease; • severe asthma, emphysema, chronic obstructive pulmonary disease (COPD) or other breathing problem; • sleep apnea (breathing stops during sleep); • glaucoma; • a stomach ulcer or digestive obstruction; • bone marrow depression; • adrenal gland tumor (pheochromocytoma); • enlarged prostate or problems with urination; • low levels of calcium in your blood (hypocalcemia); or • if you have ever had a serious side effect while using promethazine or any other phenothiazine.
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